產(chǎn)品屬性：
產(chǎn)品名稱 | Propafenone-d5 (hydrochloride) |
規(guī)格 | 1mg、5mg |
貨號(hào) | EY-01Y17358 |
Cas No.: 1346605-05-7
別名: N/A
化學(xué)名: N/A
分子式: C21H22D5NO3?HCl
分子量: 382.9
溶解度: DMSO: soluble,Methanol: soluble
儲(chǔ)存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Propafenone-d5 is intended for use as an internal standard for the quantification of propafenone by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent.1 It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 μM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 μM, respectively).1,2 Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.2,3,4 In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.5 Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.1.Delgado, C., Tamargo, J., D., H., et al.Effects of propafenone on calcium current in guinea-pig ventricular myocytesBr. J. Pharmacol.108(3)721-727(1993)
2.Christé, G., Tebbakh, H., ?imurdová, M., et al.Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytesEur. J. Pharmacol.373(2-3)223-232(1999)
3.Delpón, E., Valenzuela, C.F., Pérez, O., et al.Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating componentCirc. Res.76(2)223-235(1995)
4.Aoyama, K., Ishikuro, E., Noriduki, H., et al.Formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of Fusarium semitectum on sorghum and ratios in naturally contaminated sorghumFood Hyg. Saf. Sci.56(6)247-251(2015)
5.Germiniani, H., and Germiniani, C.Effect of propafenone hydrochloride in ventricular arrhythmias experimentally induced by barium chlorideArq. Bras. Cardiol.36(2)101-105(1981)
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