產(chǎn)品屬性：
產(chǎn)品名稱 | Rac-PT2399 |
規(guī)格 | 5mg、10mg、50mg、100mg |
貨號(hào) | EY-01Y12566 |
Cas No.: 1672662-07-5
別名: N/A
化學(xué)名: N/A
分子式: C17H10F5NO4S
分子量: 419.32
溶解度: Soluble in DMSO
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].IC50: 0.01 μM (HIF-2α)[1][1]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.
特別提醒公司產(chǎn)品僅供科研使用
